Prevalence of tablet splitting in a brazilian tertiary care hospital. International Journal of Clinical Pharmacy, 37(6), 1235–1241. Tablet splitting of narrow therapeutic index drugs: a nationwide survey in Taiwan. Cost-savings from an antipsychotic tablet-splitting program. Farmacopeia Brasileira (6a ed.), Fundação Oswaldo Cruz. Agência Nacional de Vigilância Sanitária. ![]() In vitro-In vivo correlation (IVIVC) models for metformin after administration of modified-release (MR) oral dosage forms to healthy human volunteers. Asia Oceania Journal of Nuclear Medicine & Biology, 6(2), 108–112. Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer. Īshrafpour, R., Ayati, N., Sadeghi, R., Zare Namdar, S., Ayati, N., Ghahremani, S., & Zakavi, S. Journal of Pharmacy and Pharmacology, 69(5), 603–612. Accuracy of tablet splitting and liquid measurements: an examination of who, what and how. N., Gudka, S., Locher, C., Razaghikashani, M., & Lim, L. The XR tablets containing 1000 mg of metformin hydrochloride might be eligible for division, however, manufacturers could provide appropriate scores in the tablets surfaces to make the splitting proper and safer for the patients.Ību-Geras, D., Hadziomerovic, D., Leau, A., Khan, R. In addition, nor the drug release mechanism neither the release kinetics were significantly affected. However, it was evidenced by the F2 bootstrapping parameter that splitting MetCl XR tablets did not significantly impact the in vitro drug release profiles as compared to the whole tablets. The halved tablets were more fragile and presented lower uniformity of mass and dosage unit as compared to the whole ones. ![]() Tablets containing 1000 mg of MetCl were halved (test samples) and compared with whole tablets of products containing 500 mg of MetCl (reference samples). We performed quality control assays and comparative dissolution profile studies among several medicines containing 500 mg and 1000 mg of MetCl, marketed in Brazil and Argentina. The aim of work was to evaluate the effects of splitting on the in vitro performance of XR tablets containing MetCl. Although extended-release (XR) tablets containing 500 mg, 850 mg, and 1000 mg of MetCl are marketed, it is not uncommon to split the tablet when the dosage form of the required strength is not available commercially. ![]() Metformin hydrochloride (MetCl) is used worldwide in the treatment of type-2 diabetes mellitus. Metformin hydrochloride Drug release Dissolution Quality control Diabetes mellitus.
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